Synthetic Validation Library
15 fully de-identified synthetic cases. Use them to demonstrate clinical patterns or validate engine behavior against the canonical CPE-001 rule set.
Overt primary hypothyroidism with autoimmune support
Recognize overt biochemical pattern and separate autoimmune etiology from functional state.
Antibody positive with euthyroid function
Prevent treatment/functional failure classification from antibody positivity alone.
Mild subclinical pattern with positive Anti-TPO
Recognize possible subclinical pattern while prohibiting automatic therapy.
TSH at or above 10 with normal FT4
Avoid labeling severe TSH elevation as overt when FT4 remains within range.
Pregnancy context with mild TSH elevation and Anti-TPO positivity
Route to pregnancy-specific pathway and prevent universal TSH >2.5 rule.
Preconception infertility context
Route guideline-sensitive fertility case without automatic treatment.
Central hypothyroidism after traumatic brain injury
Detect safety-critical central pattern despite normal TSH.
Low FT4 with inappropriately mild TSH elevation and pituitary history
Prevent missed central dysfunction when TSH is not low.
Thyrotoxicosis with Anti-TPO positivity
Prevent premature hashitoxicosis diagnosis.
Postpartum overt hypothyroid pattern with iron deficiency context
Detect overt pattern while routing postpartum context.
LDL and CK pattern without thyroid labs
Use metabolic/muscular findings as screening trigger only.
Biotin use with discordant apparent thyrotoxicosis labs
Surface assay interference review.
Severe decompensation risk alert
Escalate severe clinical pattern without routine outpatient framing.
Amiodarone-associated overt biochemical pattern
Detect functional pattern and show medication etiology modifier.
No biochemical thyroid dysfunction with depression-like symptoms
Demonstrate restraint when symptoms lack thyroid biochemical pattern.