Synthetic validation environment — no real patient data. Physician adjudication required.
CPE-003 · Acceptance fixtures

Synthetic CKD Validation Library

Fully de-identified synthetic cases used to demonstrate deterministic CKD pattern behavior, AKI safety gating, CGA classification, and medication-safety routing. These cases do not represent validated real-world diagnostic performance.

CKD-FX-001
Classification

Persistent moderately increased albuminuria with preserved GFR

Detect confirmed early CKD without reduced eGFR

CKD G1A2DET-001CHR-001GFR-001CGA-001CGA-002CGA-004
Load case
CKD-FX-002
Classification

Persistent severely increased albuminuria with mildly decreased GFR

Ensure G2A3 is not collapsed into A2

CKD G2A3DET-001CHR-001GFR-001CGA-001CGA-002CGA-004
Load case
CKD-FX-003
Classification

Single reduced eGFR without chronicity

Prevent false-positive CKD confirmation

kidney_abnormality_unconfirmedDET-001CHR-003GFR-003
Load case
CKD-FX-004
Safety Gate

Acute creatinine rise before CKD staging

Run AKI gate first

acute_process_possibleSAFE-AKI-001
Load case
CKD-FX-005
Classification

Isolated suspected G3a requiring cystatin C confirmation support

Confirm eGFRcr-cys workflow

GFR-003
Load case
CKD-FX-006
Classification

Combined eGFR reclassification support

Use combined equation when cystatin C available

GFR-002
Load case
CKD-FX-007
Classification

Confirmed CKD G3bA3 with diabetes

Detect high-risk diabetic kidney disease pattern

CKD G3bA3CAUSE-001KFRE-001REF-001
Load case
CKD-FX-008
Classification

Active glomerular disease red flag

Flag urgent glomerular pattern rather than benign CKD stage only

urgent_red_flagSAFE-GN-001REF-001
Load case
CKD-FX-009
Classification

Anemia in CKD context without overdiagnosing EPO deficiency

Require workup before causal claim

ANEMIA-001
Load case
CKD-FX-010
Classification

Vitamin D low alone does not establish CKD-MBD

Prevent inappropriate CKD-MBD treatment output

Load case
CKD-FX-011
Safety Gate

Severe potassium elevation with eGFR unknown

Fire global safety alert independently of CKD status

urgent_red_flagSAFE-K-001
Load case
CKD-FX-012
Safety Gate

Metformin contraindication threshold

Apply FDA renal impairment safety logic

MED-MET-001
Load case
CKD-FX-013
Classification

Kidney failure range does not automatically mandate dialysis

Avoid unsafe KRT statement

CKD G5A3REF-001KFRE-001
Load case
CKD-FX-014
Classification

Possible monoclonal protein-related kidney disease

Use UACR/uPCR discrepancy and systemic features

CAUSE-003CAUSE-004REF-001
Load case
CKD-FX-015
Medication Safety

ACE inhibitor monitoring rather than automatic cessation

Support guideline-concordant medication stewardship

MED-RASI-001
Load case
CKD-FX-016
Classification

ACE inhibitor creatinine rise requiring evaluation

Flag >30% change without automatic stop statement

MED-RASI-001MED-RASI-002
Load case
CKD-FX-017
Classification

UACR positive random sample requires confirmation

Implement sample-specific confirmation logic

kidney_abnormality_unconfirmedACR-001
Load case
CKD-FX-018
Classification

Transient UACR confounder

Prevent albuminuria diagnosis during active UTI

ACR-001ACR-002
Load case
CKD-FX-019
Classification

Possible obstructive kidney process

Detect reversible etiologic concern

SAFE-OBS-001REF-001
Load case
CKD-FX-020
Classification

SGLT2i early eGFR dip

Prevent misclassification as drug harm without red flags

MED-SGLT2-001
Load case
Validation-only · Synthetic clinical cases · Physician adjudication required. Outputs demonstrate engine behavior and safety routing — not real-world diagnostic performance. CPE-003 never confirms CKD from a single abnormal lab and never autonomously recommends dialysis, ESA, calcitriol, phosphate binders, or medication discontinuation.